What is the best grain for 45 Long Colt?

Ultimately, the best grain for .45 Long Colt ammo depends on your specific needs, here are a few options: 

• 200 Grain: This is a lighter bullet option and is often used for target shooting, plinking, and cowboy action shooting. It generally has less recoil, allowing for faster follow-up shots.
• 225-250 Grain: This is a popular weight range for .45 Long Colt ammunition and offers a good balance between recoil, accuracy, and stopping power. It is commonly used for self-defense, hunting medium-sized game, and general-purpose shooting.

Heavier Bullets (255-300+ Grain): These heavier bullets are typically used for hunting larger game or when maximum penetration and energy transfer are desired. They can provide increased stopping power and are suitable for hunting big game animals such as deer, wild boar, and even bear.