Is a 45 Long Colt more powerful than a 375 Magnum?

No, the .45 Long Colt is generally not more powerful than the .375 Magnum. The .375 Magnum, also known as the .375 H&H Magnum, is a rifle cartridge designed for hunting large and dangerous game. It typically fires a heavier bullet at higher velocities, delivering greater energy and penetration compared to the .45 Long Colt.